|
Symbol Name ID |
Ccl2
C-C motif chemokine ligand 2 MGI:98259 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Epistaxis |
Joint hemorrhage |
Persistent bleeding after trauma |
Bruising susceptibility |
Petechiae |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Hemolytic anemia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Leukopenia |
Abnormal thrombosis |
Arterial thrombosis |
Superficial thrombophlebitis |
Abnormality of thrombocytes |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Elevated erythrocyte sedimentation rate |
| Disease(s) Associated with CCL2 | ||||||||||||||||||||||||||
| Behcet's disease | ||||||||||||||||||||||||||
| pancreatitis | ||||||||||||||||||||||||||
| systemic lupus erythematosus | ||||||||||||||||||||||||||
| temporal arteritis | ||||||||||||||||||||||||||
| thrombocytopenia |
| Mouse Phenotypes | abnormal dendritic cell chemotaxis |
abnormal macrophage chemotaxis |
impaired macrophage chemotaxis |
abnormal leukocyte migration |
increased neutrophil cell number |
decreased dendritic cell number |
increased CD4-positive, alpha-beta T cell number |
decreased lymphocyte cell number |
decreased macrophage cell number |
increased osteoclast cell number |
decreased leukocyte cell number |
abnormal monocyte morphology |
abnormal neutrophil physiology |
increased IgG1 level |
increased IgG level |
abnormal T cell physiology |
abnormal macrophage physiology |
abnormal microglial cell physiology |
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| Availability | Mouse Genotype | ||||||||||||||||||
| Ccl2tm1.1Tyos/Ccl2tm1.1Tyos | |||||||||||||||||||
| Ccl2tm1Lex/Ccl2tm1Lex | * | ||||||||||||||||||
| Ccl2tm1Rol/Ccl2tm1Rol | |||||||||||||||||||
| Ccl2tm1Rol/Ccl2tm1Rol Tg(Ccr2-GFP)8Pam/0 |
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| Ccl2tm1.1Pame/Ccl2tm1.1Pame Tg(Nes-cre)1Kln/0 (conditional) |
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| Ccl2tm1.1Pame/Ccl2tm1.1Pame Tg(Tek-cre)12Flv/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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